How Harry Osborn is central to the entire story of Marvel's Spider-Man

Marvel's Spider-Man immediately throws players into the action with a siege on Fisk Tower, and while Peter Parker has already been Spider-Man for eight years at this point, he's incredibly humble in his opening sequences. Marvel's Spider-Man thrives when immersed in original stories, even if many of these moments lean heavily on comic book influences like Mr. Negative and Devil's Breath, and it's not until Marvel's Spider-Man 2 that the true nebulous character of the narrative is fully revealed. Players learn throughout Marvel's Spider-Man that Harry Osborn suffers from an illness and that his father Norman goes to extremes to cure him.

Norman Osborn can be obnoxious whenever he faces the public, especially when he gets the chance to punch a Dr. Otto Octavius, quietly enraged. However, he is clearly deeply disturbed by his son's condition and is probably still grieving the loss of his wife. Harry is then released from the stasis chamber Marvel's Spider-Man 2which therefore unleashes an alien symbiote. As such, Harry is the root of every major story development in Marvel's Spider-Man serials and Norman's wild attempts to cure him are at least partially to blame for the multiple main antagonists that have appeared.

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Harry Osborn is a tragic character at the heart of Marvel's Spider-Man

Not unlike many classic Spider-Man stories, the Osborns are the centerpiece of Marvel's Spider-Man the franchise. Insomniac weaves this story intriguingly because neither Harry nor Norman are particularly bad people. Norman only tried to heal Harry, while Harry tried to “heal the world” in honor of his mother, but it was through their actions that calamity and conflict arose in two out of three. Marvel's Spider-Man games so far:

Norman was only developing Devil's Breath (or GR-27) as a means of curing Harry Marvel's Spider-Manthough it is incomplete and Otto captures it to wield as a bioweapon.
The symbiotic bond with Harry was a means of curing him or at least keeping him in stasis while other solutions could be discovered, but his parasitic hive mind wreaks havoc on Marvel's Spider-Man 2 once Harry is freed and the symbiote briefly latches onto Peter.
Norman asking for G-SERUM at the end Marvel's Spider-Man 2 it's yet another attempt to heal Harry, and will no doubt result in a Goblin opponent, whether it's Norman, Harry, or someone else entirely.

Harry has always been selfless as shown in Marvel's Spider-Manhis research stations and Marvel's Spider-Man 2Emily-May's Foundation. There will be a new core edition of EMF in Peter's garage waiting for Harry if he manages to recover in Marvel's Spider-Man 3but whenever Norman fails to save him, it seems that Harry is doomed to a sad fate that his father was only able to postpone for so long.

Either way, there wouldn't be any devil breath outbreak or symbiote invasion if it weren't for Harry's illness, and that same illness is guaranteed to catalyze anything. Marvel's Spider-Man 3and his plot revolves around him.

The decline of Norman Osborn precipitates a green goblin in Marvel's Spider-Man 3

If Norman experiments on Harry with the G-SERUM, there is a high probability that Harry will become another villain in Marvel's Spider-Manthis time with a glider, pumpkin bombs and an armored suit. That said, doubling Harry as the villain would be weird and abuse the character more than he already was.

Norman's intentions are sincere, but Harry is more of a lab rat than anything right now. Still, there's no logical reason why Norman would take the G-SERUM in his place, and if he does become the Green Goblin, hopefully there'll be a decent explanation.